Arginine methylation of the p30 C/EBPα oncoprotein regulates progenitor proliferation and myeloid differentiation

Summary: The transcription factor CCAAT enhancer binding protein alpha (C/EBPα) is a master regulator of myelopoiesis. CEBPA encodes a long (p42) and a truncated (p30) protein isoform from a single mRNA. Mutations that abnormally enhance expression of p30 are associated with acute myelogenous leukem...

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發表在:	iScience
Main Authors:	Linh T. Nguyen, Karin Zimmermann, Elisabeth Kowenz-Leutz, Dorothea Dörr, Anja Schütz, Jörg Schönheit, Alexander Mildner, Achim Leutz
格式:	Article
語言:	英语
出版:	Elsevier 2024-11-01
主題:	biochemistry cell biology transcriptomics
在線閱讀:	http://www.sciencedirect.com/science/article/pii/S2589004224024246