The prognostic impact of KRAS, TP53, STK11 and KEAP1 mutations and their influence on the NLR in NSCLC patients treated with immunotherapy

Background: PD-L1 expression is used to predict NSCLC response to ICIs, but its performance is suboptimal. The impact of KRAS mutations in these patients is unclear. Studies evaluating co-mutations in TP53, STK11 and KEAP1 as well as the NLR showed that they may predict the benefit of ICIs. Patients...

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Bibliographic Details

Published in:	Cancer Treatment and Research Communications
Main Authors:	Francis Proulx-Rocray, Bertrand Routy, Rami Nassabein, Wiam Belkaid, Danh Tran-Thanh, Julie Malo, Marion Tonneau, Omar El Ouarzadi, Marie Florescu, Mustapha Tehfe, Normand Blais
Format:	Article
Language:	English
Published:	Elsevier 2023-01-01
Subjects:	NSCLC Immunotherapy KRAS STK11 KEAP1
Online Access:	http://www.sciencedirect.com/science/article/pii/S2468294223000898