Bone-targeting engineered small extracellular vesicles carrying anti-miR-6359-CGGGAGC prevent valproic acid-induced bone loss

Abstract The clinical role and underlying mechanisms of valproic acid (VPA) on bone homeostasis remain controversial. Herein, we confirmed that VPA treatment was associated with decreased bone mass and bone mineral density (BMD) in both patients and mice. This effect was attributed to VPA-induced el...

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Bibliographic Details

Published in:	Signal Transduction and Targeted Therapy
Main Authors:	Xudong Xie, Peng Cheng, Liangcong Hu, Wu Zhou, Detai Zhang, Samuel Knoedler, Guodong Liu, Yuan Xiong, Hang Xue, Yiqiang Hu, Barbara Kern, Doha Obed, Adriana C. Panayi, Lang Chen, Chenchen Yan, Ze Lin, Guandong Dai, Bobin Mi, Yingze Zhang, Guohui Liu
Format:	Article
Language:	English
Published:	Nature Publishing Group 2024-01-01
Online Access:	https://doi.org/10.1038/s41392-023-01726-8