Different NGS identification methods of somatic mutation sites in solid tumors impact TMB results

Abstract Background Tumor mutation burden (TMB) is a predictive biomarker for assessing the response of various tumor types to immune checkpoint inhibitors (ICI). TMB is quantified based on somatic mutations identified by next-generation sequencing (NGS) using targeted panel data. This study aimed t...

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Bibliographic Details

Published in:	BMC Cancer
Main Authors:	Xueshu Chen, Haixing Chen, Mi Liu, Mi Li, Fujuan Zhang, Weiwei Ouyang, Xiaoxu Li, Yong Yang, Niya Long
Format:	Article
Language:	English
Published:	BMC 2025-03-01
Subjects:	Solid tumor Next-generation sequencing TMB Somatic mutation
Online Access:	https://doi.org/10.1186/s12885-025-13719-7