Targeting myeloid cells to improve cancer immune therapy

Tumor immunosuppression remains a major barrier to effective cancer immunotherapy and is often driven by the immunoregulatory activities of innate immune cells, such as myeloid cells within the tumor microenvironment (TME). Myeloid populations—including tumor-associated macrophages (TAMs), dendritic...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Hui Chen, Zihan Xu, Judith Varner
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-07-01
Subjects:	myeloid cell tumor associated macrophage (TAM) PI3Kgamma TREM2 CSF1R (colony stimulating factor 1 receptor) Axl
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1623436/full