ATM/ATR Phosphorylation of CtIP on Its Conserved Sae2-like Domain Is Required for Genotoxin-Induced DNA Resection but Dispensable for Animal Development

Homology-directed repair (HDR) of double-strand DNA breaks (DSBs) is dependent on enzymatic resection of DNA ends by the Mre11/Rad50/Nbs1 complex. DNA resection is triggered by the CtIP/Sae2 protein, which allosterically promotes Mre11-mediated endonuclease DNA cleavage at a position internal to the...

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Bibliographic Details

Published in:	Cells
Main Authors:	Foon Wu-Baer, Madeline Wong, Lydia Tschoe, Chyuan-Sheng Lin, Wenxia Jiang, Shan Zha, Richard Baer
Format:	Article
Language:	English
Published:	MDPI AG 2023-12-01
Subjects:	DNA resection DNA break repair homologous recombination CtIP Mre11 ATM/ATR phosphorylation
Online Access:	https://www.mdpi.com/2073-4409/12/23/2762