Single-nucleus multi-omics of Parkinson’s disease reveals a glutamatergic neuronal subtype susceptible to gene dysregulation via alteration of transcriptional networks

Abstract The genetic architecture of Parkinson’s disease (PD) is complex and multiple brain cell subtypes are involved in the neuropathological progression of the disease. Here we aimed to advance our understanding of PD genetic complexity at a cell subtype precision level. Using parallel single-nuc...

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Bibliographic Details

Published in:	Acta Neuropathologica Communications
Main Authors:	E. Keats Shwab, Daniel C. Gingerich, Zhaohui Man, Julia Gamache, Melanie E. Garrett, Gregory E. Crawford, Allison E. Ashley-Koch, Geidy E. Serrano, Thomas G. Beach, Michael W. Lutz, Ornit Chiba-Falek
Format:	Article
Language:	English
Published:	BMC 2024-07-01
Subjects:	Parkinson’s disease Single-nucleus (sn)RNA-seq snATAC-seq Candidate cis regulatory element (cCRE) Regulatory networks Glutamatergic neurons
Online Access:	https://doi.org/10.1186/s40478-024-01803-1