Systematic in vivo analysis of the intrinsic determinants of amyloid Beta pathogenicity.

Protein aggregation into amyloid fibrils and protofibrillar aggregates is associated with a number of the most common neurodegenerative diseases. We have established, using a computational approach, that knowledge of the primary sequences of proteins is sufficient to predict their in vitro aggregati...

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Bibliographic Details

Published in:	PLoS Biology
Main Authors:	Leila M Luheshi, Gian Gaetano Tartaglia, Ann-Christin Brorsson, Amol P Pawar, Ian E Watson, Fabrizio Chiti, Michele Vendruscolo, David A Lomas, Christopher M Dobson, Damian C Crowther
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2007-10-01
Online Access:	https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.0050290&type=printable