Non-BRCA1/BRCA2 high-risk familial breast cancers are not associated with a high prevalence of BRCAness

Abstract Background Familial breast cancer is in most cases unexplained due to the lack of identifiable pathogenic variants in the BRCA1 and BRCA2 genes. The somatic mutational landscape and in particular the extent of BRCA-like tumour features (BRCAness) in these familial breast cancers where germl...

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Bibliographic Details

Published in:	Breast Cancer Research
Main Authors:	Lars v. B. Andersen, Martin J. Larsen, Helen Davies, Andrea Degasperi, Henriette Roed Nielsen, Louise A. Jensen, Lone Kroeldrup, Anne-Marie Gerdes, Anne-Vibeke Lænkholm, Torben A. Kruse, Serena Nik-Zainal, Mads Thomassen
Format:	Article
Language:	English
Published:	BMC 2023-06-01
Subjects:	Breast cancer Hereditary breast cancer Non-BRCA1/BRCA2 Whole genome sequencing Mutational signatures HRDetect
Online Access:	https://doi.org/10.1186/s13058-023-01655-y