Identification of ERAD-dependent degrons for the endoplasmic reticulum lumen

Degrons are minimal protein features that are sufficient to target proteins for degradation. In most cases, degrons allow recognition by components of the cytosolic ubiquitin proteasome system. Currently, all of the identified degrons only function within the cytosol. Using Saccharomyces cerevisiae,...

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Bibliographic Details

Published in:	eLife
Main Authors:	Rachel Sharninghausen, Jiwon Hwang, Devon D Dennison, Ryan D Baldridge
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2024-11-01
Subjects:	degrons protein degradation endoplasmic reticulum associated degradation ERAD
Online Access:	https://elifesciences.org/articles/89606