IRL790 modulated striatal D1 neurons synaptic plasticity ameliorating levodopa-induced dyskinesia in mouse

ObjectiveLevodopa (L-dopa) therapy is the principal pharmacological treatment for Parkinson’s disease (PD). Nevertheless, prolonged use of this drug may result in different involuntary movement symptoms caused by the medication, referred to as levodopa-induced dyskinesia (LID). LID is associated wit...

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Bibliographic Details

Published in:	Frontiers in Aging Neuroscience
Main Authors:	Xiaofei Wang, Wangming Zhang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-05-01
Subjects:	levodopa-induced dyskinesia dopamine D3 receptor structural plasticity functional plasticity Parkinson’s disease
Online Access:	https://www.frontiersin.org/articles/10.3389/fnagi.2024.1401991/full