Competition between skin antimicrobial peptides and commensal bacteria in type 2 inflammation enables survival of S. aureus

Summary: During inflammation, the skin deploys antimicrobial peptides (AMPs) yet during allergic inflammation it becomes more susceptible to Staphylococcus aureus. To understand this contradiction, single-cell sequencing of Il4ra−/− mice combined with skin microbiome analysis reveals that lower prod...

Full description

Bibliographic Details

Published in:	Cell Reports
Main Authors:	Teruaki Nakatsuji, Samantha L. Brinton, Kellen J. Cavagnero, Alan M. O’Neill, Yang Chen, Tatsuya Dokoshi, Anna M. Butcher, Olive C. Osuoji, Faiza Shafiq, Josh L. Espinoza, Christopher L. Dupont, Tissa R. Hata, Richard L. Gallo
Format:	Article
Language:	English
Published:	Elsevier 2023-05-01
Subjects:	CP: Microbiology CP: Immunology
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124723005053