Pancreatic β-cell hyper-O-GlcNAcylation leads to impaired glucose homeostasis in vivo

Protein O-GlcNAcylation is a nutrient and stress-sensitive protein post-translational modification (PTM). The addition of an O-GlcNAc molecule to proteins is catalyzed by O-GlcNAc transferase (OGT), whereas O-GlcNAcase (OGA) enzyme is responsible for removal of this PTM. Previous work showed that OG...

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الحاوية / القاعدة:	Frontiers in Endocrinology
المؤلفون الرئيسيون:	Seokwon Jo, Samantha Pritchard, Alicia Wong, Nandini Avula, Ahmad Essawy, John Hanover, Emilyn U. Alejandro
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	Frontiers Media S.A. 2022-10-01
الموضوعات:	O‐linked N‐acetylglucosamine (O‐GlcNAc) O-GlcNAcylation O-GlcNAcase (OGA) beta cell (β‐cell) insulin insulin secretion
الوصول للمادة أونلاين:	https://www.frontiersin.org/articles/10.3389/fendo.2022.1040014/full