Comparative transcriptional analysis identifies genes associated with the attenuation of Theileria parva infected cells after long-term in vitro culture

Abstract Autologous administration of attenuated Theileria parva-infected cells induces immunity to T. parva in cattle. The mechanism of attenuation, however, is largely unknown. Here, we used RNA sequencing of pathogenic and attenuated T. parva-infected T-cells to elucidate the transcriptional chan...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Elisabeth M. D. L. van der Heijden, Lucas Lefevre, Anton Gossner, Thomas Tzelos, Timothy K. Connelley, Musa A. Hassan
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-04-01
Online Access:	https://doi.org/10.1038/s41598-024-59197-y