CAR T-cell-associated neurotoxicity in central nervous system hematologic disease: Is it still a concern?

Chimeric antigen receptor (CAR) T-cell systemic immunotherapy has revolutionized how clinicians treat several refractory and relapsed hematologic malignancies. Due to its peculiar mechanism of action, CAR T-cell-based therapy has enlarged the spectrum of neurological toxicities. CAR T-cell-associate...

Full description

Bibliographic Details

Published in:	Frontiers in Neurology
Main Authors:	Roser Velasco, Alberto Mussetti, Macarena Villagrán-García, Anna Sureda
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-04-01
Subjects:	CAR T-cell therapy CNS relapse ICANS CNS infiltration leukemia lymphoma
Online Access:	https://www.frontiersin.org/articles/10.3389/fneur.2023.1144414/full