2′-deoxy-ADPR activates human TRPM2 faster than ADPR and thereby induces higher currents at physiological Ca2+ concentrations

TRPM2 is a Ca2+ permeable, non-selective cation channel in the plasma membrane that is involved in the innate immune response regulating, for example, chemotaxis in neutrophils and cytokine secretion in monocytes and macrophages. The intracellular adenine nucleotides ADP-ribose (ADPR) and 2′-deoxy-A...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:Frontiers in Immunology
المؤلفون الرئيسيون: Jelena Pick, Simon Sander, Stefanie Etzold, Anette Rosche, Henning Tidow, Andreas H. Guse, Ralf Fliegert
التنسيق: مقال
اللغة:الإنجليزية
منشور في: Frontiers Media S.A. 2024-01-01
الموضوعات:
TRPM2
ADPr
2′-deoxy-ADPR
calcium signaling
calcium sensitivity
calmodulin
الوصول للمادة أونلاين:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1294357/full

الانترنت

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1294357/full

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