Conditional knockdown of hepatic PCSK9 ameliorates high-fat diet-induced liver inflammation in mice

InstructionAccumulating evidence has shown that proprotein convertase subtilisin/kexin type 9 (PCSK9) is associated with inflammation in the vascular system. However, the roles of PCSK9 in hepatic inflammation remain unclear. Because PCSK9 is mainly expressed in the liver and modulates lipid uptake...

Full description

Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Xue-Ying Zhang, Qing-Qing Lu, Yan-Jie Li, Shan-Rui Shi, Chao-Nan Ma, Miao Miao, Shou-Dong Guo
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-02-01
Subjects:	inflammation MAPK PCSK9 inhibitor PCSK9 siRNA Toll-like receptor
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1528250/full