Computational remodeling of an enzyme conformational landscape for altered substrate selectivity
Abstract Structural plasticity of enzymes dictates their function. Yet, our ability to rationally remodel enzyme conformational landscapes to tailor catalytic properties remains limited. Here, we report a computational procedure for tuning conformational landscapes that is based on multistate design...
| 發表在: | Nature Communications |
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| Main Authors: | , , , , , , , , |
| 格式: | Article |
| 語言: | 英语 |
| 出版: |
Nature Portfolio
2023-09-01
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| 在線閱讀: | https://doi.org/10.1038/s41467-023-41762-0 |