A monomeric mycobacteriophage immunity repressor utilizes two domains to recognize an asymmetric DNA sequence
Bacteriophage repressor proteins downregulate viral lytic gene expression. Herein, the authors present the X-ray crystal structure of a monomeric repressor that binds an asymmetric DNA sequence using two independent domains.
| Published in: | Nature Communications |
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| Main Authors: | , , , , , , , , , , , |
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-07-01
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| Online Access: | https://doi.org/10.1038/s41467-022-31678-6 |
| _version_ | 1852663324944105472 |
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| author | Reliza J. McGinnis Chad A. Brambley Brandon Stamey William C. Green Kimberly N. Gragg Erin R. Cafferty Thomas C. Terwilliger Michal Hammel Thomas J. Hollis Justin M. Miller Maria D. Gainey Jamie R. Wallen |
| author_facet | Reliza J. McGinnis Chad A. Brambley Brandon Stamey William C. Green Kimberly N. Gragg Erin R. Cafferty Thomas C. Terwilliger Michal Hammel Thomas J. Hollis Justin M. Miller Maria D. Gainey Jamie R. Wallen |
| author_sort | Reliza J. McGinnis |
| collection | DOAJ |
| container_title | Nature Communications |
| description | Bacteriophage repressor proteins downregulate viral lytic gene expression. Herein, the authors present the X-ray crystal structure of a monomeric repressor that binds an asymmetric DNA sequence using two independent domains. |
| format | Article |
| id | doaj-art-c5e01eafbf234add839bb6caacf2cd40 |
| institution | Directory of Open Access Journals |
| issn | 2041-1723 |
| language | English |
| publishDate | 2022-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| spelling | doaj-art-c5e01eafbf234add839bb6caacf2cd402025-08-19T21:36:02ZengNature PortfolioNature Communications2041-17232022-07-0113111510.1038/s41467-022-31678-6A monomeric mycobacteriophage immunity repressor utilizes two domains to recognize an asymmetric DNA sequenceReliza J. McGinnis0Chad A. Brambley1Brandon Stamey2William C. Green3Kimberly N. Gragg4Erin R. Cafferty5Thomas C. Terwilliger6Michal Hammel7Thomas J. Hollis8Justin M. Miller9Maria D. Gainey10Jamie R. Wallen11Western Carolina University, Department of Chemistry and PhysicsMiddle Tennessee State University, Department of ChemistryWestern Carolina University, Department of Chemistry and PhysicsWestern Carolina University, Department of Chemistry and PhysicsWestern Carolina University, Department of Chemistry and PhysicsWestern Carolina University, Department of Chemistry and PhysicsNew Mexico ConsortiumMolecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National LaboratoryDepartment of Biochemistry, Wake Forest University School of Medicine, Medical Center BoulevardMiddle Tennessee State University, Department of ChemistryWestern Carolina University, Department of Chemistry and PhysicsWestern Carolina University, Department of Chemistry and PhysicsBacteriophage repressor proteins downregulate viral lytic gene expression. Herein, the authors present the X-ray crystal structure of a monomeric repressor that binds an asymmetric DNA sequence using two independent domains.https://doi.org/10.1038/s41467-022-31678-6 |
| spellingShingle | Reliza J. McGinnis Chad A. Brambley Brandon Stamey William C. Green Kimberly N. Gragg Erin R. Cafferty Thomas C. Terwilliger Michal Hammel Thomas J. Hollis Justin M. Miller Maria D. Gainey Jamie R. Wallen A monomeric mycobacteriophage immunity repressor utilizes two domains to recognize an asymmetric DNA sequence |
| title | A monomeric mycobacteriophage immunity repressor utilizes two domains to recognize an asymmetric DNA sequence |
| title_full | A monomeric mycobacteriophage immunity repressor utilizes two domains to recognize an asymmetric DNA sequence |
| title_fullStr | A monomeric mycobacteriophage immunity repressor utilizes two domains to recognize an asymmetric DNA sequence |
| title_full_unstemmed | A monomeric mycobacteriophage immunity repressor utilizes two domains to recognize an asymmetric DNA sequence |
| title_short | A monomeric mycobacteriophage immunity repressor utilizes two domains to recognize an asymmetric DNA sequence |
| title_sort | monomeric mycobacteriophage immunity repressor utilizes two domains to recognize an asymmetric dna sequence |
| url | https://doi.org/10.1038/s41467-022-31678-6 |
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