Differential radiosensitivity phenotypes of DNA-PKcs mutations affecting NHEJ and HRR systems following irradiation with gamma-rays or very low fluences of alpha particles.

We have examined cell-cycle dependence of chromosomal aberration induction and cell killing after high or low dose-rate γ irradiation in cells bearing DNA-PKcs mutations in the S2056 cluster, the T2609 cluster, or the kinase domain. We also compared sister chromatid exchanges (SCE) production by ver...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Yu-Fen Lin, Hatsumi Nagasawa, John B Little, Takamitsu A Kato, Hung-Ying Shih, Xian-Jin Xie, Paul F Wilson, John R Brogan, Akihiro Kurimasa, David J Chen, Joel S Bedford, Benjamin P C Chen
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2014-01-01
Online Access:	https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0093579&type=printable