Immunogenicity and efficacy of intramuscular replication-defective and subunit vaccines against herpes simplex virus type 2 in the mouse genital model.

Herpes simplex virus type 2 (HSV-2) is a sexually transmitted virus that is highly prevalent worldwide, causing a range of symptoms that result in significant healthcare costs and human suffering. ACAM529 is a replication-defective vaccine candidate prepared by growing the previously described dl5-2...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Simon Delagrave, Hector Hernandez, Changhong Zhou, John F Hamberger, Sophia T Mundle, John Catalan, Simge Baloglu, Stephen F Anderson, Joshua M DiNapoli, Patricia Londoño-Hayes, Mark Parrington, Jeffrey Almond, Harry Kleanthous
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2012-01-01
Online Access:	http://europepmc.org/articles/PMC3469653?pdf=render