Distinct impacts of each anti-anti-sigma factor ortholog of the chlamydial Rsb partner switching mechanism on development in Chlamydia trachomatis

ABSTRACT Partner switching mechanisms (PSMs) are signal transduction systems comprised of a sensor phosphatase (RsbU), an anti-sigma factor (RsbW, kinase), an anti-anti-sigma factor (RsbV, the RsbW substrate), and a target sigma factor. Chlamydia spp. are obligate intracellular bacterial pathogens o...

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Bibliographic Details

Published in:	Microbiology Spectrum
Main Authors:	Shiomi Junker, Vandana Singh, Aamal G. M. Al-Saadi, Nicholas A. Wood, Scott D. Hamilton-Brehm, Scot P. Ouellette, Derek J. Fisher
Format:	Article
Language:	English
Published:	American Society for Microbiology 2024-12-01
Subjects:	RsbV anti-anti-sigma factor Chlamydia development phosphorylation
Online Access:	https://journals.asm.org/doi/10.1128/spectrum.01846-24