Tonabersat enhances temozolomide‐mediated cytotoxicity in glioblastoma by disrupting intercellular connectivity through connexin 43 inhibition

Glioblastoma cells rely on connexin 43 (Cx43)‐based gap junctions (GJs) for intercellular communication, enabling them to integrate into a widely branched malignant network. Although there are promising prospects for new targeted therapies, the lack of clinically feasible GJ inhibitors has impeded t...

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Bibliographic Details

Published in:	Molecular Oncology
Main Authors:	Elena N. C. Schmidt, Bernd O. Evert, Barbara E. F. Pregler, Ahmad Melhem, Meng‐Chun Hsieh, Markus Raspe, Hannah Strobel, Julian Roos, Torsten Pietsch, Patrick Schuss, Pamela Fischer‐Posovszky, Mike‐Andrew Westhoff, Michael Hölzel, Ulrich Herrlinger, Hartmut Vatter, Andreas Waha, Matthias Schneider, Anna‐Laura Potthoff
Format:	Article
Language:	English
Published:	Wiley 2025-03-01
Subjects:	cell death connexin 43 glioblastoma tonabersat tumor microtubes tumor networks
Online Access:	https://doi.org/10.1002/1878-0261.13786