Benzo[g]quinazolin-based scaffold derivatives as dual EGFR/HER2 inhibitors

Targeting EGFR has proven to be beneficial in the treatment of several types of solid tumours. So, a series of novel 2-(4-oxo-3-(4-sulfamoylphenyl)-3,4-dihydrobenzo[g]quinazolin-2-ylthio)-N-substituted acetamide 5–19 were synthesised from the starting material 4-(2-mercapto-4-oxobenzo[g]quinazolin-3...

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Bibliographic Details

Published in:	Journal of Enzyme Inhibition and Medicinal Chemistry
Main Authors:	Mostafa M. Ghorab, Mansour S. Alsaid, Aiten M. Soliman, Abdullah A. Al-Mishari
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2018-01-01
Subjects:	Benzo[g]quinazolin benzenesulfonamide EGFR HER2
Online Access:	http://dx.doi.org/10.1080/14756366.2017.1389922