Epistasis at the cell surface: what is the role of Erg3 loss-of-function in acquired echinocandin resistance?

ABSTRACT Echinocandins, which target the fungal β-1,3-glucan synthase (Fks), are essential for treating invasive fungal infections, yet resistance is increasingly reported. While resistance typically arises through mutations in Fks hotspots, emerging evidence suggests a contributing role of changes...

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Bibliographic Details

Published in:	mBio
Main Authors:	Hans Carolus, Judith Díaz-García, Vladislav Biriukov, Stef Jacobs, Dimitrios Sofras, Alicia Pageau, Celia Lobo Romero, Lore Vinken, Pilar Escribano, Jesús Guinea, Katrien Lagrou, Christian R. Landry, Toni Gabaldón, Patrick Van Dijck
Format:	Article
Language:	English
Published:	American Society for Microbiology 2025-10-01
Subjects:	echinocandins β‑1,3‑glucan synthase (Fks) C-5 sterol desaturase (Erg3) epistasis multidrug resistance Nakaseomyces glabratus
Online Access:	https://journals.asm.org/doi/10.1128/mbio.01419-25