NRX-101 (D-cycloserine plus lurasidone) vs. lurasidone for the maintenance of initial stabilization after ketamine in patients with severe bipolar depression with acute suicidal ideation and behavior: a randomized prospective phase 2 trial

Abstract Background We tested the hypothesis that, after initial improvement with intravenous ketamine in patients with bipolar disorder (BD) with severe depression and acute suicidal thinking or behavior, a fixed-dose combination of oral D-cycloserine (DCS) and lurasidone (NRX-101) can maintain imp...

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Bibliographic Details

Published in:	International Journal of Bipolar Disorders
Main Authors:	Andrew Nierenberg, Philip Lavin, Daniel C. Javitt, Richard Shelton, Michael T. Sapko, Sanjay Mathew, Robert E. Besthof, Jonathan C. Javitt
Format:	Article
Language:	English
Published:	SpringerOpen 2023-08-01
Subjects:	Bipolar disorder Depression Suicidal ideation Ketamine Lurasidone Hydrochloride Cycloserine
Online Access:	https://doi.org/10.1186/s40345-023-00308-5