Antagonistic nanobodies implicate mechanism of GSDMD pore formation and potential therapeutic application

Abstract Inflammasome activation results in the cleavage of gasdermin D (GSDMD) by pro-inflammatory caspases. The N-terminal domains (GSDMDNT) oligomerize and assemble pores penetrating the target membrane. As methods to study pore formation in living cells are insufficient, the order of conformatio...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Lisa D. J. Schiffelers, Yonas M. Tesfamariam, Lea-Marie Jenster, Stefan Diehl, Sophie C. Binder, Sabine Normann, Jonathan Mayr, Steffen Pritzl, Elena Hagelauer, Anja Kopp, Assaf Alon, Matthias Geyer, Hidde L. Ploegh, Florian I. Schmidt
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-09-01
Online Access:	https://doi.org/10.1038/s41467-024-52110-1