Optimization of an Injectable Hydrogel Depot System for the Controlled Release of Retinal-Targeted Hybrid Nanoparticles

A drawback in the development of treatments that can reach the retina is the presence of barriers in the eye that restrain compounds from reaching the target. Intravitreal injections hold promise for retinal delivery, but the natural defenses in the vitreous can rapidly degrade or eliminate therapeu...

Full description

Bibliographic Details

Published in:	Pharmaceutics
Main Authors:	Ilaria Ottonelli, Andrea Bighinati, Elisa Adani, François Loll, Riccardo Caraffi, Maria Angela Vandelli, Frank Boury, Giovanni Tosi, Jason Thomas Duskey, Valeria Marigo, Barbara Ruozi
Format:	Article
Language:	English
Published:	MDPI AG 2022-12-01
Subjects:	nanomedicine targeted nanoparticles injectable hydrogel hyaluronic acid poloxamer 407 PLGA
Online Access:	https://www.mdpi.com/1999-4923/15/1/25