Injectable self-healing hydrogel with siRNA delivery property for sustained STING silencing and enhanced therapy of intervertebral disc degeneration

Inflammatory responses of nucleus pulposus (NP) can induce imbalanced anabolism and catabolism of extracellular matrix, and the cytosolic dsDNA accumulation and STING–NF–κB pathway activation found in NP inflammation are considered as fairly important cause of intervertebral disc (IVD) degeneration....

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Bibliographic Details

Published in:	Bioactive Materials
Main Authors:	Jiaxin Chen, Haifeng Zhu, Yutao Zhu, Chenchen Zhao, Shengyu Wang, Yixin Zheng, Ziang Xie, Yang Jin, Honghai Song, Linjun Yang, Jin Zhang, Jiayong Dai, Zhijun Hu, Huaiyu Wang
Format:	Article
Language:	English
Published:	KeAi Communications Co., Ltd. 2022-03-01
Subjects:	STING IVD degeneration siRNA delivery Injectable hydrogel Dynamic Schiff base
Online Access:	http://www.sciencedirect.com/science/article/pii/S2452199X21003704