Deciphering lentiviral Vpr/Vpx determinants required for HUSH and SAMHD1 antagonism highlights the molecular plasticity of these evolutionary conflicts

ABSTRACT SAMHD1 and the HUSH complex constitute two blocks during primate lentivirus infection, the first by limiting reverse transcription and the second by inhibiting proviral expression. Vpr and Vpx of specific lentiviral lineages have evolved to antagonize these antiviral proteins. While the ant...

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發表在:	Journal of Virology
Main Authors:	Pauline Larrous, Cassandre Garnier, Marina Morel, Michael M. Martin, Karima Zarrouk, Sarah Maesen, Roy Matkovic, Andrea Cimarelli, Lucie Etienne, Florence Margottin-Goguet
格式:	Article
語言:	英语
出版:	American Society for Microbiology 2025-05-01
主題:	HIV SIV restriction factors coevolution HUSH SAMHD1
在線閱讀:	https://journals.asm.org/doi/10.1128/jvi.00198-25