Enhancing the Conformational Stability of the cl-Par-4 Tumor Suppressor via Site-Directed Mutagenesis

Intrinsically disordered proteins play important roles in cell signaling, and dysregulation of these proteins is associated with several diseases. Prostate apoptosis response-4 (Par-4), an approximately 40 kilodalton proapoptotic tumor suppressor, is a predominantly intrinsically disordered protein...

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Bibliographic Details

Published in:	Biomolecules
Main Authors:	Samjhana Pandey, Krishna K. Raut, Antoine Baudin, Lamya Djemri, David S. Libich, Komala Ponniah, Steven M. Pascal
Format:	Article
Language:	English
Published:	MDPI AG 2023-04-01
Subjects:	intrinsically disordered proteins (IDPs) prostate apoptosis response-4 (Par-4) tumor suppressor site-directed mutagenesis circular dichroism (CD) spectroscopy dynamic light scattering (DLS)
Online Access:	https://www.mdpi.com/2218-273X/13/4/667