Bi-directional allosteric pathway in NMDA receptor activation and modulation

Abstract N-methyl-D-aspartate (NMDA) receptors are ionotropic glutamate receptors involved in learning and memory. NMDA receptors primarily comprise two GluN1 and two GluN2 subunits. The GluN2 subunit dictates biophysical receptor properties, including the extent of receptor activation and desensiti...

Full description

Bibliographic Details

Published in:	Nature Communications
Main Authors:	Paula A. Bender, Subhajit Chakraborty, Ryan J. Durham, Vladimir Berka, Elisa Carrillo, Vasanthi Jayaraman
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-10-01
Online Access:	https://doi.org/10.1038/s41467-024-53181-w