Tryptophanyl-tRNA Synthetase 1 Signals Activate TREM-1 via TLR2 and TLR4

Tryptophanyl-tRNA synthetase 1 (WARS1) is an endogenous ligand of mammalian Toll-like receptors (TLR) 2 and TLR4. Microarray data, using mRNA from WARS1-treated human peripheral blood mononuclear cells (PBMCs), had indicated WARS1 to mainly activate innate inflammatory responses. However, exact mole...

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Bibliographic Details

Published in:	Biomolecules
Main Authors:	Tram T. T. Nguyen, Hee Kyeong Yoon, Yoon Tae Kim, Yun Hui Choi, Won-Kyu Lee, Mirim Jin
Format:	Article
Language:	English
Published:	MDPI AG 2020-09-01
Subjects:	tryptophanyl-tRNA synthetase 1 TREM-1 MyD88 TRIF innate immunity
Online Access:	https://www.mdpi.com/2218-273X/10/9/1283