Craniofacial and cardiac defects in chd7 zebrafish mutants mimic CHARGE syndrome

Congenital heart defects occur in almost 80% of patients with CHARGE syndrome, a sporadically occurring disease causing craniofacial and other abnormalities due to mutations in the CHD7 gene. Animal models have been generated to mimic CHARGE syndrome; however, heart defects are not extensively descr...

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Bibliographic Details

Published in:	Frontiers in Cell and Developmental Biology
Main Authors:	Yuhan Sun, S. Ram Kumar, Chee Ern David Wong, Zhiyu Tian, Haipeng Bai, J. Gage Crump, Ruchi Bajpai, Ching Ling Lien
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-12-01
Subjects:	CHD7 CHARGE syndrome craniofacial development cardiovascular aortic arch arteries zebrafish
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2022.1030587/full