Low nephron endowment increases susceptibility to renal stress and chronic kidney disease

Preterm birth results in low nephron endowment and increased risk of acute kidney injury (AKI) and chronic kidney disease (CKD). To understand the pathogenesis of AKI and CKD in preterm humans, we generated potentially novel mouse models with a 30%–70% reduction in nephron number by inhibiting or de...

وصف كامل

التفاصيل البيبلوغرافية

الحاوية / القاعدة:	JCI Insight
المؤلفون الرئيسيون:	Pamela I. Good, Ling Li, Holly A. Hurst, Ileana Serrano Herrera, Katherine Xu, Meenakshi Rao, David A. Bateman, Qais Al-Awqati, Vivette D. D’Agati, Frank Costantini, Fangming Lin
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	American Society for Clinical investigation 2023-02-01
الموضوعات:	Nephrology
الوصول للمادة أونلاين:	https://doi.org/10.1172/jci.insight.161316