Fibroblast growth factor receptor signaling in estrogen receptor-positive breast cancer: mechanisms and role in endocrine resistance

Fibroblast Growth Factor Receptors (FGFRs) play a significant role in Estrogen Receptor-positive (ER+) breast cancer by contributing to tumorigenesis and endocrine resistance. This review explores the structure, signaling pathways, and implications of FGFRs, particularly FGFR1, FGFR2, FGFR3, and FGF...

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Bibliographic Details

Published in:	Frontiers in Oncology
Main Authors:	Arnaldo Marin, Fernanda Morales, Benjamín Walbaum
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-07-01
Subjects:	endocrine resistance FGFR signaling breast cancer ER positive TKI - tyrosine kinase inhibitor
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2024.1406951/full