Ca²⁺/Sr²⁺ Selectivity in Calcium-Sensing Receptor (CaSR): Implications for Strontium’s Anti-Osteoporosis Effect

The extracellular calcium-sensing receptor (CaSR) controls vital bone cell functions such as cell growth, differentiation and apoptosis. The binding of the native agonist (Ca²⁺) to CaSR activates the receptor, which undergoes structural changes that trigger a cascade of events...

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Bibliographic Details

Published in:	Biomolecules
Main Authors:	Diana Cheshmedzhieva, Sonia Ilieva, Eugene A. Permyakov, Sergei E. Permyakov, Todor Dudev
Format:	Article
Language:	English
Published:	MDPI AG 2021-10-01
Subjects:	calcium-sensing receptor (CaSR) Ca<sup>2+</sup>/Sr<sup>2+</sup> selectivity Mg<sup>2+</sup> DFT/PCM calculations CaSR agonists osteoporosis
Online Access:	https://www.mdpi.com/2218-273X/11/11/1576