Porphyromonas gingivalis-induced periodontitis promotes neuroinflammation and neuronal loss associated with dysfunction of the brain barrier

BackgroundIn our previous study, Porphyromonas gingivalis (P. gingivalis)-induced periodontitis caused cognitive impairment which was associated with abnormal amyloid β (Aβ) metabolite in the brain. The brain barrier is critical in maintaining homeostasis, controlling influx and efflux transport and...

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Bibliographic Details

Published in:	Frontiers in Cellular and Infection Microbiology
Main Authors:	Yiting Jiang, Lina Xu, Xuri Zhao, Hui Shen, Che Qiu, Zhiyan He, Zhongchen Song, Wei Zhou
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-06-01
Subjects:	periodontitis P. gingivalis tau hyperphosphorylation brain barrier cognitive impairment
Online Access:	https://www.frontiersin.org/articles/10.3389/fcimb.2025.1559182/full