Structural insights into the allosteric inhibition of P2X4 receptors

Abstract P2X receptors are ATP-activated cation channels, and the P2X4 subtype plays important roles in the immune system and the central nervous system, particularly in neuropathic pain. Therefore, P2X4 receptors are of increasing interest as potential drug targets. Here, we report the cryo-EM stru...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Cheng Shen, Yuqing Zhang, Wenwen Cui, Yimeng Zhao, Danqi Sheng, Xinyu Teng, Miaoqing Shao, Muneyoshi Ichikawa, Jin Wang, Motoyuki Hattori
Format:	Article
Language:	English
Published:	Nature Portfolio 2023-10-01
Online Access:	https://doi.org/10.1038/s41467-023-42164-y