Translocation pause of remdesivir-containing primer/template RNA duplex within SARS-CoV-2’s RNA polymerase complexes

The mechanism of remdesivir incorporation into the RNA primer by the RNA-dependent RNA polymerase (RdRp) of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) remains to be fully established at the molecular level. Here, we compare molecular dynamics (MD) simulations after incorporation of...

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Bibliographic Details

Published in:	Frontiers in Molecular Biosciences
Main Authors:	Yuanjun Shi, Jimin Wang, Victor S. Batista
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-10-01
Subjects:	RDV remdesivir primer extension pause MD simulation pyrophosphorylysis translocation
Online Access:	https://www.frontiersin.org/articles/10.3389/fmolb.2022.999291/full