The IL1-IL1RAP axis plays an important role in the inflammatory leukemic niche that favors acute myeloid leukemia proliferation over normal hematopoiesis

Upregulation of the plasma membrane receptor IL1RAP in acute myeloid leukemia (AML) has been reported but its role in the context of the leukemic bone marrow niche is unclear. Here, we studied the signaling events downstream of IL1RAP in relation to leukemogenesis and normal hematopoiesis. High IL1...

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Bibliographic Details

Published in:	Haematologica
Main Authors:	Bauke de Boer, Sofia Sheveleva, Katja Apelt, Edo Vellenga, André B. Mulder, Gerwin Huls, Jan Jacob Schuringa
Format:	Article
Language:	English
Published:	Ferrata Storti Foundation 2020-10-01
Online Access:	https://haematologica.org/article/view/10071