Metformin Is a Direct SIRT1-Activating Compound: Computational Modeling and Experimental Validation

Metformin has been proposed to operate as an agonist of SIRT1, a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase that mimics most of the metabolic responses to calorie restriction. Herein, we present an in silico analysis focusing on the molecular docking and dynamic simulation of the...

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Bibliographic Details

Published in:	Frontiers in Endocrinology
Main Authors:	Elisabet Cuyàs, Sara Verdura, Laura Llorach-Parés, Salvador Fernández-Arroyo, Jorge Joven, Begoña Martin-Castillo, Joaquim Bosch-Barrera, Joan Brunet, Alfons Nonell-Canals, Melchor Sanchez-Martinez, Javier A. Menendez
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-11-01
Subjects:	metformin SIRT1 aging NAD+ NAD loss
Online Access:	https://www.frontiersin.org/article/10.3389/fendo.2018.00657/full