Kaposiform lymphangiomatosis effectively treated with MEK inhibition

Abstract Kaposiform lymphangiomatosis (KLA) is a rare lymphatic anomaly primarily affecting the mediastinum with high mortality rate. We present a patient with KLA and significant disease burden harboring a somatic point mutation in the Casitas B lineage lymphoma (CBL) gene. She was treated with MEK...

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Bibliographic Details

Published in:	EMBO Molecular Medicine
Main Authors:	Jessica B Foster, Dong Li, Michael E March, Sarah E Sheppard, Denise M Adams, Hakon Hakonarson, Yoav Dori
Format:	Article
Language:	English
Published:	Springer Nature 2020-09-01
Subjects:	CBL proto‐oncogene kaposiform lymphangiomatosis lymphatic abnormality MAP kinase signaling system trametinib
Online Access:	https://doi.org/10.15252/emmm.202012324