Robo2 acts in trans to inhibit Slit-Robo1 repulsion in pre-crossing commissural axons

During nervous system development, commissural axons cross the midline despite the presence of repellant ligands. In Drosophila, commissural axons avoid premature responsiveness to the midline repellant Slit by expressing the endosomal sorting receptor Commissureless, which reduces surface expressio...

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Bibliographic Details

Published in:	eLife
Main Authors:	Timothy A Evans, Celine Santiago, Elise Arbeille, Greg J Bashaw
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2015-07-01
Subjects:	axon guidance midline slit robo receptor growth cone
Online Access:	https://elifesciences.org/articles/08407