Remyelination-Promoting DNA Aptamer Conjugate Myaptavin-3064 Binds to Adult Oligodendrocytes In Vitro

We previously applied Systematic Evolution of Ligands by EXponential enrichment (SELEX) technology to identify myelin-specific DNA aptamers, using crude mouse central nervous system myelin as bait. This selection identified a 40-nucleotide aptamer (LJM-3064). Multiple biotinylated LJM-3064 molecules...

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Bibliographic Details

Published in:	Pharmaceuticals
Main Authors:	Mahboubeh Fereidan-Esfahani, Wei Ying Yue, Brandon Wilbanks, Aaron J. Johnson, Arthur E. Warrington, Charles L. Howe, Moses Rodriguez, Louis J. Maher
Format:	Article
Language:	English
Published:	MDPI AG 2020-11-01
Subjects:	multiple sclerosis DNA aptamer human oligodendroglial cell line oligodendrocytes oligodendrocyte progenitor cells (OPCs)
Online Access:	https://www.mdpi.com/1424-8247/13/11/403