Generation of a PXR reporter human induced pluripotent stem cell line (PXR-mCherry hiPSC) using the CRISPR/Cas9 system

Pregnane X receptor (PXR) is a key nuclear receptor that mediates drug metabolism and stimulates hepatocyte proliferation. However, the lack of PXR expression in human pluripotent stem cell-derived hepatocytes limits their application for drug screening and toxicity testing. Here, we generated a PXR...

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Bibliographic Details

Published in:	Stem Cell Research
Main Authors:	Hyemin Kim, Ji-Woo Kim, So-Jin Kim, Young-Jun Choi, Dae-Sung Kim, Han-Jin Park
Format:	Article
Language:	English
Published:	Elsevier 2018-01-01
Online Access:	http://www.sciencedirect.com/science/article/pii/S1873506117302507