Endogenous p53 inhibitor TIRR dissociates systemic metabolic health from oncogenic activity

Summary: It is unclear whether metabolic health corresponds to reduced oncogenesis or vice versa. We study Tudor-interacting repair regulator (TIRR), an inhibitor of p53 binding protein 1 (53BP1)-mediated p53 activation, and the physiological consequences of enhancing tumor suppressor activity. Dele...

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Bibliographic Details

Published in:	Cell Reports
Main Authors:	Eva Tsaousidou, Jędrzej Chrzanowski, Pascal Drané, Grace Y. Lee, Nadine Bahour, Zeqiu Branden Wang, Shijun Deng, Zhe Cao, Kaimeng Huang, Yizhou He, Mateusz Kaminski, Dominika Michalek, Ekin Güney, Kalindi Parmar, Wojciech Fendler, Dipanjan Chowdhury, Gökhan S. Hotamışlıgil
Format:	Article
Language:	English
Published:	Elsevier 2024-06-01
Subjects:	CP: Cancer CP: Metabolism
Online Access:	http://www.sciencedirect.com/science/article/pii/S221112472400665X