Inhibition of fucosylation by 2-fluorofucose attenuated acetaminophen-induced liver injury via its anti-inflammation and anti-oxidative stress effects

Fucosylation is a common glycan terminal modification, which has been reported to be inhibited by 2-fluorofucose (2FF) both in vivo and in vitro. The present study aimed to investigate the effect of 2FF on acetaminophen (APAP)-induced acute liver injury, and further clarified the possible mechanisms...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Zhaoguo Liu, Mengjue Tu, Jianan Shi, Hong Zhou, Guoliang Meng, Jianguo Gu, Yuqin Wang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-09-01
Subjects:	fucosylation 2-fluorofucose acetaminophen liver injury oxidative stress
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2022.939317/full