A Facile Synthesis of 3‐Substituted Coumarins and Investigation of Their 3CLpro Inhibition Activity Against SARS‐CoV‐2

Abstract The major threat to public health due to the outbreak of severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) infection has been recognised as a global issue. The increase in morbidity is primarily due to the lack of SARS‐CoV‐2 specific drugs. One of the major strategies to combat t...

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Bibliographic Details

Published in:	ChemistryOpen
Main Authors:	Manoj K. Choudhary, Khalid Ansari, Vivek Junghare, Sandip K. Nayak, Saugata Hazra, Soumyaditya Mula
Format:	Article
Language:	English
Published:	Wiley-VCH 2025-05-01
Subjects:	Coumarins Morita-Baylis-Hillman adducts Friedel-Crafts alkylation 3CLpro Inhibitors SARS-CoV-2 Molecular Dynamics simulation
Online Access:	https://doi.org/10.1002/open.202400319