Virtual Screening for Identification of Dual Inhibitors against CDK4/6 and Aromatase Enzyme

CDK4/6 and aromatase are prominent targets for breast cancer drug discovery and are involved in abnormal cell proliferation and growth. Although aromatase inhibitors have proven to be effective (for example exemestane, anastrozole, letrozole), resistance to treatment eventually occurs through the ac...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Tenzin Adon, Dhivya Shanmugarajan, Hissana Ather, Shaik Mohammad Asif Ansari, Umme Hani, SubbaRao V. Madhunapantula, Yogish Kumar Honnavalli
Format:	Article
Language:	English
Published:	MDPI AG 2023-03-01
Subjects:	dual inhibitor CDK4/6 aromatase structure-based pharmacophore molecular docking MD simulations
Online Access:	https://www.mdpi.com/1420-3049/28/6/2490